Applying the PAM50 to the 55 tumor samples gave representatives of all five subtypes, while the paired normal tissue was predominantly of normal-like subtype.
The image data sets predominantly consisted of normal cases.
The normal breast-like samples were not further considered as these specimens are predominantly composed of normal breast tissue, which precludes the correct assignment to a tumor subtype for meaningful outcome predictions [ 1, 10].> -wrap-foot> The PAM50 intrinsic subtypes were prognostic for DRFS within node-negative and node-positive patients.
One indication of this elusiveness is that the literature, in contrast to that on the neuropathology of almost any other disease, deals predominantly with measures of normal structures rather than with the demonstration and characterization of pathological structures.
Biochemical and ultrastructural analyses indicated that the mutant predominantly forms carboxysomes of normal appearance, in addition to some elongated microcompartments.
Endogenous ROS include hydroxyl radicals that are produced predominantly as byproducts of normal cellular metabolism and through leakage of electrons during the mitochondrial electron transport chain.
Aggrecan is expressed predominantly in fibrocartilaginous zone of normal tendon and ligament [ 23].
C18 is predominantly expressed by hepatocytes of normal, cirrhotic and neoplastic liver.
Interestingly, IGFBP2 is expressed predominantly in the crypts of normal colon tissue, opposite to the pattern we observed with GATA3 expression and suggesting a stem-cell-like expression pattern.
To further examine whether the moesin expression is altered in cervical cancer, the expression pattern of moesin were studied in normal cervix and human cervical cancer tissues by immunohistochemistry. Moesin was found expressed predominantly in the cytoplasm of normal and cancer cells.
Finally, the median male to female sex ratio of 11 previous epidemiological studies, wherein the majority of cases were moderately to severely retarded, was 1.9 1, versus 5.75:1 for studies of predominantly normal IQ probands [ 2].
