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The later hypothesis is supported by Walsh et al. [ 71] who observed that microsatellite unstable breast ductal carcinoma in situ were predominantly of higher nuclear grade, suggesting that aberrations in MMR function may lead to a more aggressive phenotype in breast cancer.
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When assayed using 454 sequencing, all replicates of the S-SM1 genome resulted in single contig assemblies comprised predominantly of high quality bases (Table 1).
However, DCIS detected by mammographic screening is predominantly of high nuclear grade and only 13% is low grade [ 11].
Saetren (2005) reviewed all implementation literature published and concluded that while most of the studies focused on health and education, they were predominantly of high income, Western countries.
The estates were comprised predominantly of high-rise blocks, each met the Scottish Government's definition of disadvantaged areas (Walsh, 2008), and each contained a mixture of UK-born residents and first generation migrants (mainly asylum-seekers and refugees).
Morphologically, these tumours are predominantly of high grade [ 9, 19, 23- 26, 29, 35] and more frequently show medullary-like features [ 30, 31] and metaplastic elements [ 19, 20, 32, 33, 36- 39].
On the other hand, studies by Falchetti et al (1999), Harada et al (2000), Cabuy and de Ridder (2001) and Tchirkov et al (2003) have generated conflicting results regarding the prognostic utility of telomerase expression in meningiomas and gliomas (predominantly of high grade).
Even with only ∼2× average genomic coverage, these assemblies predominantly consist of high-quality bases.
These results indicate that the Asn site predominantly consists of high-mannose type N-linked glycans.
Carcinosarcoma and undifferentiated carcinoma, which are both predominantly variants of high grade serous carcinoma, are also included in this category.
The volunteers participated in a regular and strictly controlled exercise program, which consisted predominantly of aerobic activities (high volume and different submaximal intensities), such as running and swimming.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com