In addition, we investigated whether CD8+ T cells targeting epitopes restricted by HLA-B27 and -B57, two alleles that have been associated with lower viral setpoints and long-term non-progressive HIV-1 infection, were predominantly of a terminally differentiated phenotype [28] [30] and found this not to be the case (Fig 4b).
Skeletal muscle is a complex tissue consisting predominantly of a single differentiated cell type, that is, the contractile, multinucleated myofiber.
This group comprised predominantly of well- to moderately differentiated cases (95%).
The typical patient presented with breast cancer in the upper outer quadrant, the tumor being moderately differentiated and predominantly of ductal histology.
The use of free PSA in addition to total PSA reduces the number of negative sextant biopsies at a PSA cut-off level of 3 ng/ml at initial screening with 30%, at the cost of losing 10% of detectable cancers that are predominantly well differentiated on histology.
Tumors were predominantly moderately differentiated (60%) and were of locally advanced stages III and IV (92%).
In both rat and human fetal testes, DBP exposure induced similar germ cell effects, namely, germ cell loss (predominantly undifferentiated), induction of multinucleated gonocytes (MNGs), and aggregation of differentiated germ cells, although the latter occurred rarely in the human testes.
Rex1GFP-positive cells plated in serum generate colonies of undifferentiated cells, whereas Rex1GFP-negative cells produce predominantly small, differentiated colonies.
Cdx-2 staining was predominantly observed in small cells residing in clumps, but was not detected in large nuclei of differentiated cells (Figure 2A).
Basal and stem cell enriched populations predominantly established poorly differentiated squamous tumors, whereas differentiated luminal cells gave rise to a high proportion of ER+ papillary tumors.
