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Other patients had predominantly memory dysfunction, later age of onset, and slower disease progression.
Unlike blood, synovial fluid Th cells are predominantly memory cells, so admixture of naive cells causes little or no bias in this compartment [ 34].
This observation may suggest the existence, in both groups, of an active, though predominantly memory T-cell driven, antitumor response which may benefit and respond to recall antigens from a cancer vaccine.
T cells found in the synovial joint tissue of RA patients are predominantly memory CD4+ cells [ 22], with unusual characteristics in that they are small, noncycling and nonapoptosing, but have features of activation [ 23].
The peripheral population became predominantly memory phenotype and remained largely comprised of effector and central memory cells throughout the study period, although some regeneration of naïve cells was evident within 3 months and later thereafter (Table 2 and Fig. 3B).
By looking at the healthy population, these studies are likely to be detecting predominantly memory T-cell reactivity, whereas we were studying women with recent or current disease, and are therefore likely to be detecting effector populations as well as memory.
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The former showed a predominantly effector memory (EM) phenotype (median EM/central memory frequencies 0.52%/0.34%), whereas the latter were either EM (0.33%) or central memory (0.29%).
This is in accordance with GDTc expanded from imatinib-treated CML patients, which are predominantly central memory CD45RA-CD27+ CD45RA-CD27+ral blood, yet after expansinn with bromohydrin peripheralate attain the CD45RA-CD27- effector memory phenotype (Helene Sicard, personal communication, unpublooded data).
However, short-term culture with IL-2 predominantly generates memory CAR T cell favorable for cancer treatment.
The CMV-specific CD8+ T cell response displays a predominantly late memory phenotype.
Chemo-vaccination-induced T cell responses were robust (up to 3,940 SFU/106 PBMCs), predominantly central memory cells, short-lived (≤22 weeks), and appeared intermittently and with changing specificities.
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