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Our results suggest that the slope of the amplification decline is predominantly locus- specific and will largely depend on the conservation of the sequences flanking the microsatellite repeat.
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Individuals with a predominantly external locus of control feel that external factors have greater control over their lives, demand more from others, have greater emotional and functional dependence and are more affected by criticism and praise.
Predominantly gained loci were observed at the several loci.
On the other hand, higher genetic distance at introns than at exon 2 within functional clades is expected when recombination occurs predominantly between loci [36].
However, our profile also showed that some of the LY6 family genes were not upregulated even though they are located on 8q24.3, wherein predominantly gained loci were located in the CGH array study.
We observed large effect sizes with obesity for rs10767664 (BDNF) (OR = 1.923, P = 0.00072) and rs3751812 (FTO) (OR = 1.523, P = 0.016) in our sample and, using weighted genetic risk scores, we found strong evidence of a cumulative effect using 11 SNPs taken predominantly from loci principally affecting appetite (OR = 2.57, P = 0.00092).
In the human who had been exposed to metallic mercury, mercury was seen predominantly in the locus ceruleus and corticomotor neurons, as well as in scattered glial cells.
To include more information and better reflect the original siRNA situation, 931,924 siRNA loci containing multi-reads (≤1000 locations) were used for further analysis, with more than 90% of the siRNA loci predominantly producing 24-nt siRNAs and 3% and 1% of the loci being enriched with 21- and 22-nt siRNAs, respectively (Additional file 3: Table S2).
Overall, this method provides an efficient means of isolating predominantly single-copy loci from both low and high-copy gene families, providing ample nuclear variation for reconstructing species-level phylogenies in non-model taxa.
An important difference between these studies and our study is that rather than allowing an abstract epistasis parameter to evolve, we show mechanistically how, via the interplay between the non-linear genotype phenotype mapping and the flexible genome and gene regulatory network architecture, variation becomes limited to a number of loci predominantly located in the middle of the genome.
The SCL and LMO2 loci predominantly both sustain V(D J-type D J-typet one-thirDSBs more of the DSbutare incompatible with the sequence requirements for V(D)J-type DSBs, and these may be due torfree radical damore, iofizing radiathen, or topoisomerase failures.
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