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Although coatomer has been predominantly implicated in retrograde transport of small vesicles, blocking retrograde transport should also affect anterograde transport.
The transcriptional regulation of TERT is predominantly implicated in the regulation of telomerase activity in cells.
In contrast, GATA-4, -5 and -6 are predominantly implicated in heart and gut development (Laverriere et al, 1994; Molkentin, 2000).
In contrast, neuroimaging studies of other functional neurological disorders have predominantly implicated the prefrontal cortex (Nowak and Fink, 2009; Bell et al., 2010).
Transmembrane mucins may function as cell surface receptors conducting signals leading to responses such as proliferation or apoptosis, whereas secreted mucins are predominantly implicated as a first line of defence for the epithelial surface (reviewed in Hollingsworth and Swanson, 2004).
While estrogen has normal biological roles, such as reproduction, brain development and additional protective effects of sexual steroid hormones, prolonged exposure, combined with high levels of hormone increases the risk of BC by constitutively activating the transcription of genes predominantly implicated in metabolism and cell cycle regulation.
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COX-2 has predominantly been implicated in modulating body temperature changes in response to infection.
However, expression of several other regulatory genes was significantly influenced by growth temperature, predominantly genes implicated in carbohydrate metabolism, ion uptake, and cell envelope synthesis.
These results imply that the loci are likely to be implicated predominantly in the development of moderate/severe disease.
The majority of these genes had a decreased expression in samples from breast cancer patients, and predominantly encoded proteins implicated in ribosome production and translation control.
The majority of the identified genes had a decreased expression in samples from breast cancer patients, and predominantly encoded proteins implicated in ribosome production and translation control.
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