BPDE induced predominantly G to T transversions within this target sequence.
Similarly KRAS mutations are more frequently identified in tobacco smokers and are predominantly G → T transversion mutations [31].
Gymnosperms (softwood) are usually primarily composed of G lignin [ 15], angiosperm dicots (hardwood) are composed of predominantly G and S lignins while monocots (such as grasses) usually have more H lignin content [ 3, 13].
Specifically, mutations were more frequently detected when single-stranded vectors were used with base substitutions, predominantly G to T transversions, occurring in various mammalian cell lines at frequencies from ∼4 to 11%.
In addition, a strong strand bias was found in this region (predominantly G->A mutations), which may be a result of preferential deamination on the non-transcribed strand of nearby genes.
The pattern of mutations observed with B[ a]P-7,8-dione was predominantly G to T transversions, and the pattern was remarkably similar to the mutational pattern observed in lung cancer patients.
In the case of chemically-induced mutations, frequent transition changes are expected because both EMS and MNU alkylate predominantly G residues and result in GC->AT changes [ 34, 35].
Furthermore, β2AR is predominantly Gs-coupled, the M2 receptor is Gi-coupled, but both produce similar effects when fused to Kir6.2.
In Experiment 2, eight cows were transferred to each of four diets containing concentrates with low (L) or high (H) starch content and predominantly grass (G) or maize (M) silages in a factorial design.
Moreover, the spectrum of mutations differed between sporadic colon carcinoma, where the predominant mutation was a G to A transition, and pancreatic carcinomas, which predominantly contained G to C or T transversions.
