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Our own data suggest that CovR of S. mutans predominantly functions as a repressor [27], [29], [30].
Conversely, Gli2 predominantly functions as an activator in Hh pathway, Gli2 knockdown is able to inactivate Hh signaling and mimic the phenotypes of Shh mutant.
These data imply that p14ARF predominantly functions by impeding ribosome biogenesis, causing an increase in the levels of nonribosomal 5S RNP.
Moreover, the finding that expression is comparably higher in intestinal/excretory tissues than in the carcass suggests that this transporter predominantly functions in midgut, or in Malpighian tubules.
Two families of DNMTs have been identified: DNMT1, which predominantly functions in maintenance of DNA methylation during DNA replication, and DNMT3 (including DNMT3a and DNMT3b), which is thought to be primarily responsible for de novo CpG methylation [10].
Although GLI2 predominantly functions as a full-length isoform (Pan et al., 2006), we were able to detect an equivalent amount of the cleaved isoform in both control and talpid tissue (Fig. 4A).
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Results from a genome-wide analysis of the host intracellular network that regulates survival of Mtb showed that those factors predominantly function through the regulation of autophagy (Kumar et al., 2010).
To improve understanding, we drew on a global catalytic model and previous findings to design three NOS chimeras that may predominantly function as NO dioxygenases: iNOSoxy/nNOSred (Wild type (WT) chimera), V346I iNOSoxy/nNOSred (V346I chimera) and iNOSoxy/S1412D nNOSred (S1412D chimera).
Both receptors predominantly function as non-covalently bound homodimers.
CtBP family proteins predominantly function as transcriptional factors.
Members of the 14-3-3 14-3-3 14-3-3oteukaryotic proteinnantly familyon as dimers.
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