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Both receptors predominantly function as non-covalently bound homodimers.
To improve understanding, we drew on a global catalytic model and previous findings to design three NOS chimeras that may predominantly function as NO dioxygenases: iNOSoxy/nNOSred (Wild type (WT) chimera), V346I iNOSoxy/nNOSred (V346I chimera) and iNOSoxy/S1412D nNOSred (S1412D chimera).
CtBP family proteins predominantly function as transcriptional factors.
Members of the 14-3-3 14-3-3 14-3-3oteukaryotic proteinnantly familyon as dimers.
The SLC4 solute carriers, on the other hand, predominantly function as chloride-bicarbonate and anion exchangers and sodium-bicarbonate co-transporters (NBC).
We note that some carotenoids can have a light-harvesting function in anoxygenic phototrophs and cyanobacteria but predominantly function as protectants against photooxidative stress (Cogdell et al., 2000; Glaeser and Klug, 2005; Ziegelhoffer and Donohue, 2009).
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Our own data suggest that CovR of S. mutans predominantly functions as a repressor [27], [29], [30].
Conversely, Gli2 predominantly functions as an activator in Hh pathway, Gli2 knockdown is able to inactivate Hh signaling and mimic the phenotypes of Shh mutant.
Although GLI2 predominantly functions as a full-length isoform (Pan et al., 2006), we were able to detect an equivalent amount of the cleaved isoform in both control and talpid tissue (Fig. 4A).
TBX-2 can repress gene expression in cotransfection assays in mammalian cells, and a microarray comparison of wild-type and tbx-2 (bx59 ) C. elegans embryos identified approximately 1000 genes that are upregulated and approximately 200 genes down-regulated in tbx-2 (bx59 ) mutants, suggesting that TBX-2 predominantly functions as a transcriptional repressor.
The clot formation time ([CFT], s) and α angle (α, degree), which is the slope of the tangent to the curve, express the velocity of clot formation and are affected predominantly by platelet number and function, as well as by fibrinogen activity.
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