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Although the initial clinical trials using PDGFR kinase inhibitors have been predominantly disappointing, diagnostic and treatment modalities involving genomic profiling and personalized medicine are expected to improve the therapy targeting PDGFRα signaling.
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Results from clinical trials using MMPIs have been disappointing, predominantly because of severe side effects as well as the lack of tumour responsiveness to these agents (Coussens et al, 2002).
The Clinton camp hoped that her disappointing showing in the predominantly white early nominating states would quickly be erased once the nomination process moved to states like Nevada and South Carolina, which have a more mixed ethnic and racial makeup.
To date, attempts to improve survival with innovative, predominantly anti-inflammatory therapeutic strategies have been disappointing, with the exception of physiological doses of corticosteroid replacement therapy [ 5, 6] and activated protein C (drotrecogin alfa [activated]) [ 7] in selected patients.
Although methotrexate (MTX) is often used for patients with predominantly peripheral AS and those with psoriatic arthritis, the few attempts to treat predominantly axial disease were disappointing.
Truly disappointing".
Disappointing stuff.
"Disappointing, very disappointing".
Extremely disappointing.
Really disappointing.
Kinda disappointing.
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CEO of Professional Science Editing for Scientists @ prosciediting.com