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According to the definition of tumour cell dedifferentiation in this study, 21 patients (14%) showed both well or moderately differentiated at the surface to the centre and poorly differentiated at the margin in patients with predominantly differentiated histology (n=153).
They maintained this level of cell cycle distribution after treatment, suggesting a predominantly differentiated state.
In patients with predominantly differentiated histology (n=153), prognostic values of tumour cell dedifferentiation and tumour budding were examined.
In the absence of doxycycline, only a small number of hybrid colonies were obtained (Table S5); these were predominantly differentiated and could not be expanded.
In predominantly differentiated tumour, higher TrkB at the invasive front was significantly associated with tumour budding rather than tumour cell dedifferentiation.
Further, five patients with completely or predominantly differentiated metastases in staging lymphadenectomies were found to have widespread completely or predominantly undifferentiated metastases at autopsy 4-7 years later.
Similar(51)
The use of free PSA in addition to total PSA reduces the number of negative sextant biopsies at a PSA cut-off level of 3 ng/ml at initial screening with 30%, at the cost of losing 10% of detectable cancers that are predominantly well differentiated on histology.
Tumors were predominantly moderately differentiated (60%) and were of locally advanced stages III and IV (92%).
Thus, sorting cells from the HFK according to CD24 would result in a heterogeneous population comprised predominantly of differentiated cells and to a much lesser extent of stem/progenitor cells.
NFAT5 is expressed predominantly in differentiated epithelial cells.
Most patients had rectal (32%) and sigmoid (27%) primaries, predominantly moderately differentiated (72%).
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CEO of Professional Science Editing for Scientists @ prosciediting.com