Given that miRNAs predominantly decrease the expression of their targets [ 46], we looked for predicted interactions associated with inverse correlations in miRNA and mRNA expression levels.
Gene products of several other biological processes, including vacuolar acidification, vacuolar protein sorting, vesicle-mediated transport, DNA repair and cell cycle regulation predominantly decrease the sensitivity to CG-1521.
Fenofibrate predominantly decreased triglyceride concentrations (triglycerides, −39%; p <0.005) and induced a shift in LDL subtype distribution from small, dense LDL (−31%) to intermediate-dense LDL (+36%).
In the heliosphere at solar maximum, cosmic rays undergo a "change-of-state" from a period of several years of predominantly decreasing intensity to the recovery toward the next solar minimum.
Based on the achieved mechanical, thermal, rheological, water absorption, and microstructural results, the affinity of amine functional group and HDPE matrix predominantly decreased the rigidity, improved the thermal stability, reduced the water uptake, and facilitated the dispersion of fillers within the polymeric composite.
The lipidomic screen (Figure 5B), controlled for the effects of BMI, revealed a pattern of predominantly decreased levels of LPC, PC, PC-O, PE, and SM, reaching significance only for PE 38∶2 species.
Taking a proteomic approach, we attempted to characterize the global protein expression profiles in the WAT of mice when challenged with HFD feeding, leading to the identification of lipogenic enzymes, including ACL and FAS, which exhibited most predominantly decreased expression patterns.
We find that on days 0 and 1, RNAs are predominantly decreased.
Within pathways related to the endocrine system, PPAR signaling was enriched where both protein and transcript expression was predominantly decreased (Additional file 1: Table S7).
In contrast to the module shown in Figure 6, most member genes were predominantly decreased with aging, particularly in aorta, gametes and cardiac tissue (Additional File 11).
Increasing returns to scale was the predominant form of scale inefficiency except for private hospitals that show predominantly decreasing returns to scale.
