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Extending a previous study indicating that highly interacting proteins are predominantly conserved in evolution we generalize the concept that evolutionary signals are carried by the topology of the underlying protein interaction network.
The majority of rearrangements had occurred before the Arabidopsis– Brassica split at 20 24 MYA; thus, the segmental architecture of the A. thaliana genome was predominantly conserved in Brassica[ 49, 51, 63].
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This result, like PCA, confirms that variation in transcript abundance during seed development is predominantly conserved across genotypes in B. rapa.
Alignments of RelE amino acid sequences revealed conserved residues, and highlighted regions of similarity as well as regions predominantly conserved among metagenomic sequences (Fig 5).
This implication is backed by further analyzing the correlation between gene conservation and location relative to the oriC: the core genes are found predominantly clustered around the oriC while genes conserved in only some species and the 2,967 S.
Calreticulin (CRT) is a 46 KDa multifunctional protein predominantly located in endoplasmic reticulum (ER) and highly conserved in diverse species.
Strikingly, the non-conventional β1' and β1" strands of the first WH domain of Vps25p, are only predicted to be conserved in a subset of fungi, predominantly the Saccharomycotina [ Additional File 18].
We identified 45 genes found to be conserved in 13 out of 14 strains of predominantly human listeriosis-related lineages I and II while being absent from both strains of lineage III (Additional file 19).
Second, the two baits that succeeded in identifying interacting partners are the C-terminal fragments that contain mostly regions not conserved in yeast, whereas those fragments that failed predominantly contained the polyglutamine tract, block I and/or block II, conserved regions that are known to be required for recruitment into yeast SAGA and mammalian STAGA/TFTC complexes (9, 33– 33).
The single-site C to T mutants seem to create primate-specific, predominantly highly conserved sequences because chromosomal positions of more than 90% of the examined mutant loci are conserved in the genomes of human, chimpanzee, gorilla, orangutan, and gibbon (supplementary fig. S4, Supplementary Material online).
Predominantly cytoplasmic with some nucleolar localization (Balzer and Moss, 2007; Moss et al., 1997), LIN28 is highly conserved in other mammalian genomes (Moss and Tang, 2003).
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