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Intersection of this data with whole exome results from 145 individuals with unexplained JS identified six families with predominantly compound heterozygous mutations in KIAA0586.
This gene was previously missed by exome sequencing, most likely due to a high-carrier frequency of a common allele in a predominantly compound heterozygous inheritance, thus, precluding a homozygosity mapping approach or filtering focused on rare variants.
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Perchlorate (ClO4−), a predominantly synthetic compound manufactured in the form of ammonium salt, is used primarily as an energetics booster or oxidant in solid rocket fuels and munitions (Motzer 2001).
As part of our extensive Good Laboratory Practice compliant quality control, we included reagent blanks and confirmed that samples stored for up to 10 years contained predominantly metabolized compound, confirming minimal leaching of BPA from collection or storage vessels during this time.
Mutasynthesis of some rapalogs resulted predominantly in compounds lacking late post polyketide synthase biosynthetic modifications.
As an example, the most specific structural feature for cluster 3, that comprises 98 predominantly inactive compounds, is the SMARTS fragment NC(C N.
Predominantly identified compounds were phenolic acids, which contribute ca. 40%% of total radical scavenging activity.
Propolis, a resinous hive product collected by honeybees from many plant sources, contains predominantly phenolic compounds including flavonoids, phenolic acids and their esters [ 4– 6].
It is noteworthy that the aromatic primary amine, "hydrazine," and "sulfonamide" moieties, found within compounds that are known to be toxic both in vitro and in vivo (Alaejos et al. 2008; Carr et al. 1993; Toth 1988), were found predominantly in compounds of class 1.
Juglone (5-hydroxy-1,4-naphthoquinone) is an allelopathic compound predominantly abundant in the roots, leaves, bark and wood of Juglans sp. (walnut).
For instance, polydimethylsiloxane (PDMS -covered fibers adsorb PDMS -covered non-polar compounds or Carbowax-covered fibers adsorb predominantly polar compounds.
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