Sentence examples for predominantly by binding from inspiring English sources

The cytokine IFN-γ transactivates MHC class I expression predominantly by binding to IFN regulatory factor-1, which binds, in turn, to the interferon-stimulated response element, ISRE, a GC-rich region and therefore a potential binding site also for MeCP2 [47].

Thus, the blockade of the hPD-1/hPD-L1 interaction by pembrolizumab occurs predominantly by binding to the C'D loop and overlaps binding to the C and C' strands to compete with the binding of hPD-L1.

Rb is an important regulator of the cell cycle that acts predominantly by binding to and inhibiting the gene transactivation by E2F transcription factors, which would otherwise induce the expression of genes that enhance cell cycle progression.

One strand (mature miRNA) associates with argonaute (AGO) proteins and forms a miRNA-induced silencing complex (miRISC) which recognizes the target messenger RNAs (mRNAs) predominantly by binding to the three prime untranslated region (3′ UTR) through imperfect base pairing (Krol et al. 2010).

The posttranscriptional suppression is predominantly achieved by binding the miRISC at 3′-UTR of an mRNA.

Mammalian miRNAs predominantly act by binding to the 3' untranslated region (UTR) of cognate mRNAs.

We found that ≈80% of changes in the total activation energy resulted from changes in the enzyme substrate binding energy, indicating that substrate selectivity in the small pocket is controlled predominantly by the binding step (KM) rather than the catalytic step (kcat).

Carrageenans are selective inhibitors of several enveloped and nonenveloped viruses and act predominantly by inhibiting the binding or internalization of virus into the host cells [ 32, 33].

They predominantly suppress gene expression by binding to the their target mRNAs to form RNA-induced silencing complex (RISC) [ 1] and are responsible for regulating >60% of the human coding genome [ 2- 4].

Interestingly, Disarib showed a novel mode of BCL2 inhibition, by predominantly binding to its BH1 domain, as compared to the BH3-specific action of other known BCL2 inhibitors.

By predominantly binding to high affinity sites on the growing plus ends of microtubules, eribulin inhibits microtubule polymerization without affecting depolymerization, which in turn induces irreversible mitotic block at G2-M phase and apoptosis [ 1– 6].