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While the heterodimers α2 β1 and α6 β1 mediate binding to laminin, α4 β1 and α5 β1 predominantly bind to fibronectin [ 47].
We would speculate that native A2B trimers are likely capable of binding to TACI and BCMA, whereas AB2 trimers should predominantly bind to TACI and possibly BAFF-R.
Specifically, Victoria viruses appear to have both α-2,3 and α-2,6-linked sialic acid binding capacities (Wang et al., 2012; Velkov, 2013), while Yamagata viruses predominantly bind to α-2,6-linked glycans on cells in the human respiratory tract.
Human seasonal viruses almost exclusively attach to N-acetylneuraminic (sialic) acid receptors at α-2,6 linkage, whereas avian influenza viruses predominantly bind to α-2,3 sialic acid linkage.
Even if the hypothesis has to be examined in more detail, we conclude that TcdA and TcdA1 1874 predominantly bind to different but not independent receptor structures.
Similar differences between pAKT and pERK were observed for other ligands that predominantly bind to a single RTK.
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The poly(A -binding protein PA -bindinginantly bound to mRNAs, whereas tRNAs were proteinnt targets of the nuclear surveillance factor Mtr4, consistent with rePab1s of extensive nuclear predominantlyadation (Gudipati et al., 2012bound
However, 25(OH D is predominantly bound to vitamin D binding protein in a very stable complex; indeed, only free and albumin-bound 25(OH D may be considered available for biological functions [ 3].
Tipifarnib is predominantly bound to plasma proteins (99%) (Janssen Research Foundation, 2003), whereas the binding of gemcitabine to plasma proteins is negligible (Shipley et al, 1992).
To identify the domains of Orai1 that bind α-SNAP, we tagged the cytosolic N- and C-terminal tails of Orai1 with GST, expressed them in E. coli and found that purified α-SNAP predominantly binds to the C-terminal tail of Orai1 (Orai1-CT) although faint binding to the N-terminal tail of Orai1 (Orai1-NT) walsolso detected.
Despite these differences the dissolved fraction (fd) and partitioning coefficient (Kd) distributions are similar, illustrating that P is predominantly bound to PM fractions.
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