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This supports the observation that the lack of Cot-1 RNA hybridization is not representative of genic silencing but instead reflects a repressive nuclear compartment that predominantly associates with repetitive non-genic silencing [2], [3].
MKRN1 predominantly associates with proteins involved in mRNA metabolism including regulators of mRNA turnover, transport, and/or translation.
Consistent with this, the TAF15-bound U1 snRNA efficiently protected the U1A-specific antisense RNA probe (Fig 1B), showing that TAF15 predominantly associates with the abundant U1A snRNA.
The β1 subunit remained below detection level in Caco-2/15 cells confirming that α6 predominantly associates with β4 in intestinal cells.
Herrera et al. found that TAF9B predominantly associates with the SAGA complex, rather than the TFIID complex, in the motor neuron cells.
Interestingly, the α6 integrin subunit can heterodimerize with either β1 or β4 to form the α6β1 or α6β4 integrins but in the gut epithelium as well as in CRC, the α6 integrin subunit predominantly associates with β4 (10 12).
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