Sentence examples for predominantly activating from inspiring English sources
The different sizes of the under-expressed versus over-expressed Oct4-knockdown gene sets suggested that Oct4 may be predominantly activating rather than repressing transcription (Fig. 3B).
This mechanism would be consistent with the predominantly activating effect of Rlf on transcription.
This is consistent with both approaches selectively or predominantly activating SNr projection neurons.
Together, these data are consistent with a predominantly activating effect for Htz1 at the promoters of antisense transcripts.
Comparison of strand-specific RNA-seq and ChIP-seq data shows that Htz1 occupancy has a predominantly activating effect on the promoters of antisense and sense transcripts.
While we also observe a predominantly activating effect for Htz1 at the 5′ ends of genes on sense transcripts, the effect is weaker than for antisense transcripts, as the p-values are markedly higher than at the 3′ ends (Additional file 3: Figure S3A, B, C).
It is currently thought that overstimulation of extrasynaptic NMDA receptors mediates this neuronal damage, while, in contrast, synaptic activity predominantly activates survival pathways [ 55– 55].
While several groups have previously identified hypoxia as playing a role in NFκB signalling, the mechanism whereby a decrease in available oxygen could elicit the activation of a transcription factor that is predominantly activated by more traditional receptor ligand activation signalling pathways was unclear.
CNP predominantly activates Npr2, which underlies guanylyl cyclase activity and mediates several cellsignalling effects through the synthesis of cGMP.
In macrophages stimulation with TGFβ predominantly activates the regulatory SMAD2 and −3 but activation of SMAD1 and −5 was also observed [ 5].
Owing to its function as a tumour suppressor, however, there is some evidence that PTEN has significant impact on the efficiency of targeted therapies by antagonising the activation of the PI3K AKT pathway that is predominantly activated by EGF-/HER2-receptor tyrosine kinases in different tumour types.
