Sentence examples for predominantly activates from inspiring English sources

It is currently thought that overstimulation of extrasynaptic NMDA receptors mediates this neuronal damage, while, in contrast, synaptic activity predominantly activates survival pathways [ 55– 55].

CNP predominantly activates Npr2, which underlies guanylyl cyclase activity and mediates several cellsignalling effects through the synthesis of cGMP.

As previously reported (22), activation of ΔMEKK1 ER* with 4-OHT predominantly activates JNK, with only marginal effects on p38 and ERK1/2 phosphorylation (Fig. 3 D ).

In macrophages stimulation with TGFβ predominantly activates the regulatory SMAD2 and −3 but activation of SMAD1 and −5 was also observed [ 5].

We found that TNF predominantly activates p38MAPKα and ERK in the synovial membrane, whereas JNK activation is less common.

Conversely, the G12D mutant protein predominantly activates the RAF/MAPK and PI3K pathways [14] (Fig. 1).

While several groups have previously identified hypoxia as playing a role in NFκB signalling, the mechanism whereby a decrease in available oxygen could elicit the activation of a transcription factor that is predominantly activated by more traditional receptor ligand activation signalling pathways was unclear.

Owing to its function as a tumour suppressor, however, there is some evidence that PTEN has significant impact on the efficiency of targeted therapies by antagonising the activation of the PI3K AKT pathway that is predominantly activated by EGF-/HER2-receptor tyrosine kinases in different tumour types.

In cardiomyocytes lacking β2AR, PDE4D8 was the PDE4D isoform predominantly activated after stimulation of β1AR with ISO, with a limited activation of PDE4D9, and no significant effect on PDE4D5.

In the neocortex, optogenetic ACh release from projections predominantly activate nicotinic AChR currents24,26,37,54,55.

The reference tasks predominantly activated the left frontal and temporal core language regions, respectively.