Sentence examples for predominantly activated from inspiring English sources

While several groups have previously identified hypoxia as playing a role in NFκB signalling, the mechanism whereby a decrease in available oxygen could elicit the activation of a transcription factor that is predominantly activated by more traditional receptor ligand activation signalling pathways was unclear.

Owing to its function as a tumour suppressor, however, there is some evidence that PTEN has significant impact on the efficiency of targeted therapies by antagonising the activation of the PI3K AKT pathway that is predominantly activated by EGF-/HER2-receptor tyrosine kinases in different tumour types.

In cardiomyocytes lacking β2AR, PDE4D8 was the PDE4D isoform predominantly activated after stimulation of β1AR with ISO, with a limited activation of PDE4D9, and no significant effect on PDE4D5.

The reference tasks predominantly activated the left frontal and temporal core language regions, respectively.

In general, thermal cracking of 1-heptene was mainly initialed by CC bond scission followed by free radical reaction mechanism, whereas catalytic cracking was predominantly activated by CC bond scission, protonation and dehydrogenation.

The rhl system on the other hand, is under the control of both las and pqs, yet many QS-dependent virulence factors are predominantly activated by RhlR-BHL (Latifi et al., 1995; Schuster and Greenberg, 2007; Schuster et al., 2004; Whiteley et al., 1999; Winzer et al., 2000), thus the rhl system functions like a workhorse for the QS command.

It is currently thought that overstimulation of extrasynaptic NMDA receptors mediates this neuronal damage, while, in contrast, synaptic activity predominantly activates survival pathways [ 55– 55].

CNP predominantly activates Npr2, which underlies guanylyl cyclase activity and mediates several cellsignalling effects through the synthesis of cGMP.

In macrophages stimulation with TGFβ predominantly activates the regulatory SMAD2 and −3 but activation of SMAD1 and −5 was also observed [ 5].

We found that TNF predominantly activates p38MAPKα and ERK in the synovial membrane, whereas JNK activation is less common.

Conversely, the G12D mutant protein predominantly activates the RAF/MAPK and PI3K pathways [14] (Fig. 1).