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In particular, a number of patients who show a characteristic predominant weakness of proximal muscle groups lack a genetic diagnosis.
These diseases belong to the so-called limb girdle muscular dystrophies (LGMDs), characterized by predominant weakness and wasting of muscles of the pelvic and shoulder girdle.
Such dominant-side predominant weakness has been described in other neuromuscular disorders, particularly facioscapulohumeral dystrophy, and it may reflect asymmetric muscle use.
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Conclusions: Simple VC measurement in the sitting and supine positions may be helpful in detecting severe or predominant diaphragmatic weakness.
Its geography, in combination with its porous rule of law and predominant institutional weakness, particularly in the northern and southern border regions, have turned Mexico into a criminality paradise.
The diseases are defined and classified according to their genetic cause as well as clinical and pathological manifestation, the distribution of predominant muscle weakness, and the involvement of other organs [ 77].
The predominant problems are weakness, numbness, stiffness, skin colour change and pain/aching, on exposure to cold.
This patient did not have distinguishing phenotypic features compared with other family members: she had proximal-predominant skeletal muscle weakness, respiratory muscle weakness with abnormal pulmonary function testing, and disease onset occurred at age 55 (onset age ranged from 33 to 71 years in this family).
Apart from a scapulo-peroneal distribution of weakness, a predominant limb-girdle weakness can be seen in some cases [ 13, 15].
In accordance with these clinical observations, our patient also presented predominant proximal lower limb weakness, and calf volume increase with soleus and gastrocnemius medialis involvement.
Increased protein wasting and type II muscle-fiber atrophy is associated with significant muscle weakness, with predominant involvement of the pelvic girdle musculature.
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