Although the predominant substrate for PARP-1 is itself, it also modifies histone H1 and the core histones, particularly H2B, in vivo.
Although histones are the predominant substrates identified for HKMTs, a few nonhistone substrates were identified previously such as Rubisco from plants (Houtz et al., 1989), the tumor suppressor protein p53 (Chuikov et al., 2004) and the TBP-associated factors, TAF 7 (Couture et al., 2006) and TAF10 (Kouskouti et al., 2004).
A predominant feature of CASA is that it is stress related with a predominant substrate of CASA in mechanically stressed cells being the cytoskeletal protein filamin.
Among hard and brittle materials, single crystalline silicon is the predominant substrate material for integrated circuits (IC) [1, 2, 3, 4, 5]; optical glasses are for optical windows and lens [6, 7, 8, 9, 10, 11] as well as high-power laser components [12]; ceramic materials are commonly used for bearings, cutting tools and machine parts [13, 14, 15, 16].
The predominant primary afferent substrate for electrically evoked itch in humans, using the presently applied stimulation paradigm, is concluded to be capsaicin-sensitive polymodal C-fibers.
In contrast, nutrients function by providing the normal biochemical substrates for more complex chemicals and reactions.
3. Substrates for angiogenesis.
Keeping in mind the observation that the binding affinity of CTAD was unchanged from that of WT-FIH (Table 2), we are led to conclude that the predominant role of FIH-Gln is to position substrate for a chemical step rather than to bind CTAD.
