Glucose and oxygen are the predominant substrates for the production of the ATP needed for normal peripheral nerve function [ 39].
Glucose and long-chain fatty acids (LCFA) are the predominant substrates for energy provision of the contracting heart.
Two residues in PABP1 were previously identified as predominant substrates for PRMT4-dependent arginine methylation in vivo and additional putative PRMT4-dependent methylation was also identified [ 12– 12].
A predominant feature of CASA is that it is stress related with a predominant substrate of CASA in mechanically stressed cells being the cytoskeletal protein filamin.
Among hard and brittle materials, single crystalline silicon is the predominant substrate material for integrated circuits (IC) [1, 2, 3, 4, 5]; optical glasses are for optical windows and lens [6, 7, 8, 9, 10, 11] as well as high-power laser components [12]; ceramic materials are commonly used for bearings, cutting tools and machine parts [13, 14, 15, 16].
Although histones are the predominant substrates identified for HKMTs, a few nonhistone substrates were identified previously such as Rubisco from plants (Houtz et al., 1989), the tumor suppressor protein p53 (Chuikov et al., 2004) and the TBP-associated factors, TAF 7 (Couture et al., 2006) and TAF10 (Kouskouti et al., 2004).
The predominant primary afferent substrate for electrically evoked itch in humans, using the presently applied stimulation paradigm, is concluded to be capsaicin-sensitive polymodal C-fibers.
Keeping in mind the observation that the binding affinity of CTAD was unchanged from that of WT-FIH (Table 2), we are led to conclude that the predominant role of FIH-Gln is to position substrate for a chemical step rather than to bind CTAD.
Since histone is a poor substrate for calcium-insensitive isoforms of PKC, the predominant isoforms of PKC detected were cPKC and aPKC.
For migration/invasion assay, invasion chambers coated with Matrigel (Becton and Dickinson, MA, USA) were used, while for matrix degradation [H]-collagen IV substrate was chosen as substrate, as this molecule is the predominant collagen type in the basement membrane and is the substrate for both type IV collagenases (MMP-2 and MMP-9).
