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Somnolence, sedation, constipation, thrombosis and neuropathy are predominant side effects of thalidomide, whereas neuropathy and the inconvenience of parenteral administration makes bortezomib unattractive, especially in elderly population.
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Asthenia was the predominant side effect.
As skin toxicity is a predominant side effect of many specific EGFR-TKI (Li and Perez-Soler, 2009), the question here is whether any of the other target inhibiting effects acts as main driver of the therapeutic potential of JNJ-26483327.
Therefore, it is likely that that at nanomolar or low micromolar concentrations neurotoxic side effects are predominant.
Indeed, a patient whose predominant reason for underuse of a medication is experiencing side effects but who also has concerns about the price might reasonably report CRN (9).
The predominant assumption is that highly selective ligands would avoid unwanted side effects caused by binding to secondary non-therapeutic targets.
Symptoms of MM and side effects of treatment, particularly fatigue and pain, were the predominant barriers to physical activity.
Analysis of the VDR heterodimerization partners suggests that selective vitamin D analogs activating exclusively the predominant VDR-RXR-α heterodimer may be most effective in the treatment of BCC with little risk of side effects.
In many Asian countries and other European countries, such side effects do not appear to be so treatment-limiting or predominant.
There were side effects.
Any other damaging side effects?
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