Sentence examples for predominant pathogenic role from inspiring English sources
However, no other tumours showed upregulation of ErbB2 expression or activity, implicating pathways other than ErbB2 as playing a predominant pathogenic role in these tumours.
Therefore, the possibility that his mild chronic hepatitis might have contributed to the occurrence of PVT cannot be ruled out, even though his clinical history and his previous records of coagulation parameters give a weak support to the hypothesis that the underlying liver disease played a predominant pathogenic role in the development of PVT.
Systemic effects of chelation, e.g., on the peripheral immune system, could be relevant since autoimmune reactions are generally thought to have a predominant pathogenic role in MS. Although this is important, other compounds currently in use also limit the immune response.
Aneurysms of the abdominal aorta are a particular form of atherothrombosis, in which the pathogenic role of proteolysis is predominant.
While the hSyn II mutants described here displayed a predominant loss-of-function character in primary SYN2 KO neurons, their pathogenic role in patients in whom only one allele is mutated could result from either a haploinsufficiency with impaired Syn II expression or a dominant-negative effect towards the endogenous Syn II.
"We already know that free radical damage has an important pathogenic role in heart disease and stroke," Dr. Perls said, "and it may also play an important role in Alzheimer's disease.
Hypovolemia-related hypoperfusion is probably the predominant pathogenic mechanism during the early pre-resuscitative phase.
Leukocytes play an important pathogenic role in ischaemia-reperfusion injury.
This may result in a wide variability on individual recovery time courses after optimization of DO2 depending on the predominant pathogenic mechanism.
A 2007 study proposes a pathogenic role of leukocyte recruitment in sympathetic ophthalmia.
EBV has long been suspected to play a pathogenic role in SLE.
