We found that all B-type RRs are able to interact with HPt predominant partners (HPt2, 7 and 9) of HK1, which is putatively involved in the osmosensing pathway.
The five poplar B-type RRs, RR12, 13, 14, 16 and 19, interacting with HPt2, 7 and 9, the predominant partners of HK1, and concomitantly expressed in the main organs of poplar, could be probably involved in a poplar osmosensing pathway.
Our results strongly indicate that PPARγ is the predominant heterodimerization partner for RXR during late stages of adipocyte differentiation.
Using this strategy, the 35-kDa antigen encoding a homolog of the PspA phage shock protein was identified as a predominant binding partner and substrate of PepD.
We found no evidence for a compensatory up regulation of other AKAPs (Fig. 3) and the delocalization of PKA indicates that AKAP5 is a predominant binding partner for PKA in forebrain dendritic processes.
Nuclear receptors are usually found in protein complexes as monomers, homodimers, or heterodimers [ 2], with one member of the NR2 family, the retinoid X receptor (RXR) operating as the predominant heterodimer partner in vertebrates [ 3].
Our simulations reveal how the spacious gap directionally accommodates the lesion aromatic ring system as it transits through the stages of incorporation of the predominant correct partner dCTP opposite the damaged guanine, with preservation of local active site organization for nucleotidyl transfer.
The brain is the major site of α-dystrobrevin expression, α-dystrobrevin is the predominant dystrophin partner in the brain, and α-dystrobrevin coarse isoforms have been shown to be expressed in a stringently cell-type-specific manner in the brain [ 59, 60]; the absence from mouse of >50% of the brain α-dystrobrevin isoforms means that the mouse brain DGCs are highly atypical in composition.
Although our in vitro studies pointed to CaM as most likely the predominant interacting/activating partner for CN, we speculated that the situation in the complex physiological setting of mammalian cells might not reflect the results obtained from such a comparatively simple analysis.
HCF-1 plays a key role in stem cell maintenance, at least in part by regulating genes involved in RNA splicing [ 31], and we showed here that HCF-1 is the predominant BAP1 binding partner in uveal melanoma cells, and that genes regulated by BAP1 are enriched for those involved in cell cycle control and RNA splicing and processing.
