These findings suggest that, in addition to their predominant functions in nerve conduction, oligodendrocytes may also labor as mechanical and trophic supports to axons [ 24, 26].
We enrolled 42 patients (26 males and 16 females aged 56.64 ± 12.67 years) with diabetic neuropathy defined by symmetric distally predominant sensory symptoms, abnormal nerve conduction studies, and reduced intraepidermal nerve fiber density in the leg.
The EMG-study showed a distal asymmetric polyneuropathy, predominant in the Tibial nerve.
Gangliosides, sialylated glycosphingolipids which are the predominant glycans on vertebrate nerve cell surfaces, are emerging as components of membrane rafts, where they can mediate important physiological functions.
Electrophysiological evidence of neuropathy may be mild or absent consistent with predominant involvement of small nerve fibers.
Some authors also include Moebius syndrome, which is defined by affection of cranial nerves VI and VII, and the Moebius syndrome variants (predominant affection of cranial nerves other than VI and VII) in the entity of CCDD [ 1, 2].
These include forms with only patchy sensory loss, mild electrical motor nerve abnormalities and predominant small fibre or isolated lower limb involvement.
Of these diseases, Finnish-type familial amyloidosis (FAF) is characterized by autosomal-dominant inheritance with predominant cranial involvement, particularly facial nerve involvement and corneal lattice dystrophy [ 4] and gelsolin-related amyloid deposition [ 5, 6].
Whilst the stimulation parameters used here would likely activate all classes of fibre, we have also demonstrated that the predominant fibre type within this nerve corresponds to muscle afferents.
9 Predominant involvement of small distal sensory nerve fibers has been observed across clinical studies of ixabepilone (phases I III) in patients with early and metastatic disease.
