Sentence examples for predominant negative regulator from inspiring English sources

MDM2 functions as a predominant negative regulator of p53, and it controls p53 activity and degradation through ubiquitination (Dongiovanni et al., 2010).

Overexpression of PTEN, as the predominant negative regulator of PI3K, would be expected to promote apoptosis and involution and possibly also to affect differentiation during pregnancy.

Conversely, the negative regulator GSK3β was down-regulated.

An additional member of the AP2/ERF superfamily, SlERF6, has been recently identified to play an important role in tomato fruit ripening and carotenoid accumulation acting as a negative regulator of two of the predominant nutritional compounds of tomato, lycopene and β-carotene [ 23].

TNF is a predominant proinflammatory cytokine, particularly in sepsis and chronic inflammatory disorders suggesting that the role of its negative regulator, TTP, may be of functional importance in the development and pathogenesis of disease.

In general, KDR is recognised as the predominant signal transducer of tumour angiogenesis, whereas Flt-1 (and especially its soluble form) is a negative regulator of VEGF availability (Ferrara et al, 2003).

Myostatin (MSTN) is a negative regulator of skeletal muscle mass.

These studies also indicated that SUB1A-1 might be a negative regulator of OsSUB1C.

These findings identified miR-33a as a negative regulator of breast cancer cell proliferation and metastasis.

OsWRKY42 has been characterized as a negative regulator functioning downstream of OsWRKY13.

Spl11 encodes an E3 ubiquitin ligase that functions as a negative regulator of programmed cell death.