Exact(1)
Overall, our results indicate that bile acids trigger elevation of cAMP and Ca2+ in L-cells, but that the predominant link between luminal bile acids and GLP-1 release is probably mediated by GPBAR1 located on the basolateral L-cell membrane.
Similar(59)
Understanding adiponectin transport into and across these cells holds important clues towards understanding the systemic physiological effects of this important adipocyte-derived secretory protein and may further reinforce adiponectin as a predominant hormonal link between adipose tissue health and cardiovascular disease.
Wheeler et al. [ 36] demonstrated a strong link between the predominant T-cell effectors and chemosensitivity in GBM tumors.
By analyzing MAE chromatin signature in a large number of cell and tissue types, we show that it remains consistent during terminal cell differentiation and is predominant among cell-type specific genes, suggesting a link between MAE and specification of cell identity.
Initial observations of an increased rate of hepatocellular carcinoma formation in FGF19 transgenic mice and the predominant expression of FGFR4 in the liver provided a link between FGF19-FGFR4 signanding and tumourigenesis.
Interest in the latter is rising due to the identification of cases with predominant kidney involvement and to the hypothesis of a link between mitochondrial DNA and kidney neoplasia.
The CX-MS results show that a predominant cross-linking is between Sdo1p and uL16 through Lys62 (Sdo1p)-Lys184 (uL16) (Figs. 5A, 5B and S5), which is highly consistent with previous data that uL16 is involved in Sdo1p recruitment in the late-stage maturation of the 60S subunit (Sulima et al., 2014a).
"The past several decades have witnessed rapid change in the predominant family structures and norms in the United States, and these changes may alter the link between marital status and health," they write.
Interest in kidney involvement is rising due to the identification of MELAS mutations in cases with predominant kidney involvement, occasionally with very late diagnosis, and to the description of a putative link between mitochondrial DNA and different types of kidney neoplasia [ 8- 12].
Payment by results makes an explicit link between the number of patients treated and the payment to a hospital, whereas the predominant arrangements that it replaces left this link poorly defined.
In retrospect, it appears that a major factor contributing to the relative ease with which a link between gap junction remodelling and arrhythmia in the ventricle has been established is the presence of a single predominant connexin, Cx43.
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