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We have determined that myosin II is the predominant effector molecule downstream of Rho-Rock signaling in the regulation of cell-cell contacts in ES cells.
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The identity of the effector molecule(s) is largely unknown.
Holler, N. et al. Fas triggers an alternative, caspase-8 independent caspase-8 independenting the kinase RIP as effecell molecule.
We co-transfected HeLa cells with plasmids encoding Nef-VC, MHC-I-VN-Flag and the early endosomal effector molecule mCherry-Rab5.
Collectively, these data suggest that IFN-γ is a key effector molecule of the immune system for TRC dormancy induction and maintenance in vitro.
Holler, N. et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.
Rao, V., Fujiwara, N., Porcelli, S. A. & Glickman, M. S. Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule.
In addition to conveying cellular responses to an effector molecule, receptors are often themselves regulated by their effectors.
This step is mediated by the recruitment of the Rab5 effector molecule EEA1.
Interestingly however, unlike recent reports utilizing mouse models, IL-13 was not a main effector molecule in our human system.
Unlike many known regulators of the Wnt pathway, these molecules do not affect stabilization of Arm/beta-catenin (betacat), the principal effector molecule in Wnt signal transduction.
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