Thus, it is possible that MS is associated with a predominant dysfunction of the resistance vessels and, hence, by using FMD, we did not detect significant endothelial dysfunction in our study cohort.
A predominant dysfunction of postsynaptic (inner) retinal neurons has also been indicated by electroretinographic analysis of Ppt1 and Cln3 mutant mice, as mostly b-wave amplitudes were affected [ 17, 21, 23].
Cardiac amyloidosis is an infiltrative disease causing predominant diastolic dysfunction and systolic dysfunction at its advanced stage.
Thus, the definitions that have been used conventionally are "cone dystrophy for retinal diseases with predominant cone dysfunction with later onset and mild rod involvement," and "CRD for retinal dystrophies with early onset cone dysfunction followed shortly thereafter by significant rod disease" [ 1].
Two patients (4%) did not show muscular hypotonia, but a predominant liver dysfunction, either isolated (Patient 37) or in combination with encephalopathy (Patient 39).
It may be that the secondary intrathecal synthesis of NMDAR antibodies and development of oligoclonal bands are required before there is more global cerebral involvement with predominant subcortical dysfunction, slow-wave discharges and white matter lesions.
Taken together with previous data obtained from the Ndufs4 fky/fky mice [ 12], it appears unlikely that a tissue-specific difference in CI activity is the basis for the predominant neurological dysfunction in the Ndufs4 fky/fky mouse.
The important characteristics of this type of presentation included severe weakness and wasting in C7, C8, and T1 myotomes that frequently spilled over to C6 segment, predominant autonomic dysfunction in distal upper extremities in the form of cold paresis, cold skin, excessive sweating, and hair loss over the dorsum of the hands, and a very prominent bilateral minipolymyoclonus [ 23].
The amnestic presentation, which is most common, has both impairment in memory function as well as in a second cognitive domain, while the less common non-amnestic presentations can include progressive visuospatial impairment, syndromes of predominant frontal/executive dysfunction, or language impairments with prominent naming difficulties.
With regard to the latter, one would expect greater impact from AChEIs in patients with PDD with predominant cholinergic network dysfunction, but less of an impact in patients where catecholaminergic network dysfunctions are similar or equal to cholinergic ones.
8- We suggest the use of a transpulmonary thermodilution monitor/pulse wave analysis plus measurement (continuous or intermittent) of mixed venous oxygen saturation (SvO2) or ScvO2 when cardiogenic shock is refractory to initial treatment, in the absence of mechanical assistance and of predominant right ventricular dysfunction (weak agreement).
