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Cation interstitials are the predominant defects in Y3Fe5O12 − θ.
One of the predominant defects in fra3/fra4 mutants is thinning and missing posterior commissures, with nearly a quarter [24%] of segments showing this defect ([Figure 1D], black arrowhead; graphed in K; refs [13], [32], [36]).
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Monocyte functions, however, were not altered, suggesting a predominant defect in the T cell response rather than an impaired monocyte antigen-presenting capacity.
Using two imaging techniques to track the clearance of biotransformed dyes by the liver in a rat model of intra-abdominal infection, the authors show that the predominant defect in sepsis lies in the excretion of biotransformed molecules from the hepatocyte into the bile canaliculi.
The RC defects were more severe in cerebellum with significant reductions in all of the complexes when normalized either to CS (Fig 5C) or to mg-proteins with predominant defect in complex I (29 ± 15%; P = 0.0087; n = 5; Unpaired t-test with Welch's correction) and increased CS activity (129 ± 34%) (Supplementary Table S4).
It further shows that in these genotypes the predominant defect is in the reformation of SVs during the stimulus and from bulk endosomes, with no obvious impact on their reformation from the plasma membrane after stimulation.
Whole-exome sequencing of 22 CRC genomes followed by large-cohort validation by targeted capture sequencing confirmed APC, KRAS and TP53 mutations as predominant genetic defects in our patient cohort.
Among the affected individuals, the predominant defect was a dorsal gap in one or more abdominal segments, in some cases leading to segment fusion.
This will reflect that in MODY the predominant defect is insulin secretion rather than the combined defect seen in type 2 diabetes of insulin secretion and insulin resistance, resulting in higher C-peptide whether measured in serum or urine.
In certain cases, some laboratories provided only the predominant defect of an olive oil despite the detection of more defects.
Recently, alterations in bone material properties seem to be the predominant defect leading to increased bone fragility.
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