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In conclusion, HCN4 is the predominant channel subtype in normal human heart, and its expression is further amplified by disease.
The proposed method computes each panning coefficient as the relation between the norm of each instrument at each channel in its time-frequency region and the norm of each instrument at its predominant channel in its time-frequency region (the panning coefficient for the instrument at its predominant channel is supposed to be 1).
Therefore, the autocorrelation metric is expected to work well in line-of-sight (LOS) scenarios where the most predominant channel path is the first arrival path, but it will fail in NLOS scenarios where the most predominant channel path is usually not the first arrival path.
Our algorithm shows better performance results than those of the autocorrelation-based technique in NLOS channels, where the most predominant channel path is usually not the first arrival path.
However, maximizing the autocorrelation metric over a window of length will rather provide a timing offset estimate of the most predominant channel path than a timing offset estimate of the starting position for the OFDM symbols.
One can see that the power correlation metric-based technique cannot exceed lock-in probability of 0.6 even at high SNR because the most predominant channel path is usually not the first arrival path.
In fact, the autocorrelation and MMSE metric-based techniques cannot exceed a lock-in probability of 0.5 even at high SNR because the most predominant channel path is usually not the first arrival path.
As demonstrated in Section 3, for LOS channels the most predominant channel path is the first arrival path and the transition metric is averaged over 10 blocks while the autocorrelation metric is averaged over 10 blocks times the cyclic prefix duration.
Consistent with that, modelling the permeability barrier as a mixture of two differently sized channels improved the fit considerably and yielded as best fit parameters a predominant channel radius of 2.63 nm (99.7% of the channels) and 0.33% channels with a radius of 4.32 nm (see red curve in Figure 3B).
