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The different cellular forms are classified using morphology, including the order of the nucleus, flagellum and kinetoplast along the anterior posterior axis of the cell, the predominant cell surface molecules and the location within the host.
Consistently with its predominant cell surface topology, the ∼80-kD V3Nter polypeptide was detected at much lower levels in cell conditioned media than in cell layers, even after loading a 10-fold higher amount of protein from conditioned media than from cell layers (Figure 4D).
In leukemias, the malignant cells home to the high endothelial venules of lymph nodes by way of a CD44 mechanism, the predominant cell surface receptor for HA (Zahalka et al. 1995; Wallach-Dayan et al. 2001).
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Hyaluronan (HA) is a constituent of extracellular matrix, which can induce marked effects on cell behavior by binding to its predominant cell-surface receptor CD44 [ 3].
VLA-4 is also a major contributor to plasma cell interactions with the extracellular matrix and BMSC due to its predominant expression on the plasma cell surface.
The expression of MHC antigens presenting intracellularly synthetised peptides on the cell surface is the predominant reason for immunologic detection and rejection of allogeneic cell and tissue transplants.
Because the predominant form of TEM8 on the cell surface is not recognized by SB5, we also developed a new monoclonal antibody, called AF334, which is able to recognize both the SB5-exposed and the SB5-masked forms of TEM8.
Besides that, the existing SI molecules are not properly expressed at the apical cell surface and reveal a predominant intracellular localization [25].
Alternatively, APP can be cleaved byα-secretase in the non-amyloidogenic pathway predominant in secretory vesicles and at the cell surface.
Compared to control data, a significant decrease in impedance data is observed for drug treated samples above 10 μM dose due to predominant cell death and detachment from the electrode surfaces.
Cell surface α-cleavage is the predominant processing pathway for human wild-type APP.
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