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Among the biological processes correlated with higher SUV values, the predominant biological processes have to do mainly with the tumor compartment (like ribosome biogenesis, DNA replication, and RNA processing and splicing) and also with the immune system.
GO and pathway analyses were performed to determine the predominant biological processes and pathways that are potentially regulated by the candidate genes and play a role in hypoxia tolerance.
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The predominant biological process for genes from the arctic-enriched library is "response to stimulus".
Unsurprisingly, in the case of nucleolar-cytoplasmic proteins, the most predominant biological process is protein metabolic process, which includes 106 proteins annotated with the term translation.
Another predominant biological process was related to the localization of cellular components (establishment of localization, transport, protein localization), which were ascribed to five genes.
The next most predominant biological process terms were related to the localization of cellular components (establishment of localization, transport, protein localization), which were ascribed to 33 assembled sequences.
Transport, establishment of localization, immune function, response to stimulus, biological regulation, and cell adhesion were the predominant overrepresented biological processes.
The predominant GO Biological Process categories represented by this group of co-regulated genes were not limited to a single category and overlapped with some of the categories previously reported by others [ 9, 10].
The predominant terms implicated in biological processes were "biological regulation" (GO: 0065007), "cellular progress" (GO: 0009987), "developmental progress" (GO: 0032502), "metabolic progress" (GO: 0008152) and "response to stimulus" (GO: 0050896).> -wrap-foot> Detainformationatiof of target genes for all salt-responsive miRNAs was listed in Additional file 5.
In order to identify the predominant cell populations and biological processes involved in ECM development, we clustered the genes based on their expression profiles through development, utilising both differences between time points within genotypes and differences between genotypes at the same time point.
Cluster 1 significantly (P < 0.05) defined 6 biological processes, 5 predominant molecular functions, and 1 pathway, whereas the 66 genes in cluster 2 clearly involved 6 biological processes, 7 main molecular functions, and 2 pathways (Table 1).
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