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In addition to the predominant activation of STAT3 in hepatocytes, IL-22 also activates, to a lesser extent, many other signaling pathways including AKT (as shown in Fig. 7 in this paper, and references [ 1– 3]).
The yeast one-hybrid assay revealed the predominant activation of LacZ reporter gene expression by OsSND2 under the control of OsMYB61 promoter.
Caspases 3, 9 and 7 were cleaved earlier and at lower STS doses than caspases 8 or 10, confirming the expected predominant activation of the intrinsic apoptotic pathway.
While Cluster 3, with the higher percentage of responders, seemed to show predominant activation of the Myc and Ras pathways, Cluster 4 showed activation of the Myc and E2F pathways.
For example, Kuwabara et al. (2012) showed a predominant activation of S100A8/TLR4 signaling in the glomeruli of diabetic mice.
Therefore, other mechanisms may be involved in the predominant activation of anti-apoptotic genes identified in the present study.
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Autophosphorylation has been identified as a predominant mechanism of activation of ERK7/8 [24] [26].
Rather, overexpression seems to be the predominant trait of activation of Rho signalling in breast tumours.
One can assume that the TF-dependent system plays a predominant role in activation of coagulation in sepsis.
CYP1A2 is an inducible phase I metabolizing enzyme highly active in the liver, where it plays a predominant role in the activation of HCAs [ 40], such as those found in tobacco, to reactive species that can undergo further activation in the liver or detoxification.
This unbiased screen pinpoints interference with the DNA topology as the predominant mean of pharmacological activation of the p53 pathway and identifies potential novel antitumor agents.
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