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The selection of NK cells with a predominant activating profile is critical for delivering successful anti-tumor activity.
NCR1 functions as the predominant activating NK receptor, whereas NCR2 and NCR3 have much more restricted expression profiles [ 23].
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All contained LRP4 antibodies of the predominant complement activating IgG1 subclass.
At the time of world-manifestation the active principle, rajas, becomes predominant and activates the other two principles.
Of interest, the PMAr THP-1 cells, although still showing a predominant classically activated phenotype, shifted their level of CD206 expression and became much more similar in overall phenotype to the MDM.
In contrast to this we found decreased expression of IL17, and that the predominant cell activated was the DC.
Our genome-wide array and in vitro studies have elucidated that the predominant pathway activated following exposure to ETP-45658 (as well as following PI-103 treatment) was FOXO-mediated cell cycle arrest.
Apoptotic events are closely related to caspase activity, and caspase-3, which is located downstream of the caspase cascade, plays a predominant role in activating effect or caspases that lead to apoptosis.
In this regulatory machinery, MYB proteins may play a predominant role in activating the structural genes.
They also show that signalling via the Tumour necrosis factor (TNF; also known in Drosophila as Egr) ligand is the predominant pathway that activates JNK on Rok activation.
BRAF mutations at the V600 residue are the predominant MAPK activating mutations found in cutaneous melanoma.
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