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Immunological assays detected B-cell lymphopenia with predominance of memory B cells.
It is also unclear whether this predominance of memory B cells reflects a loss of peripheral tolerance or abnormal selection processes or whether their appearance is simply the result of an enhanced activation and differentiation of naïve B cells or their insusceptibility to immunosuppressive drugs.
All of these disturbances of B-cell subsets in adults and children with lupus with a predominance of memory B cells may also contribute to the increases of plasmablasts during active lupus [ 21], which could be sufficiently blocked by anti-CD154 therapy [ 57].
Similar(57)
A more likely explanation is that the variations with age reflect the varying proportions of cell populations across the age range, with an immune system rich in precursor cells in young people and a predominance of germinal centre and memory B-cells in older adults.
In this regard, it is notable that metabolic differences have been reported in T cell subsets, with a predominance of oxidative phosphorylation associated with resting or memory T cells and aerobic glycolysis associated with activation and T helper subsets [ 22].
Memory, all kinds of memory, is exploding.
The obliteration of memory.
Feat of memory?
Source: Nelson Mandela Centre of Memory.
The Future Of Memory.
The Book of Memory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com