Even though some of the activities of IL-6 proceed via its soluble form, the predominance of complexes of IL-6 and the IL-6 receptor is the therapeutic rationale for targeting the receptor rather than the cytokine.
The predominance of ETC complex I deficiency is not unexpected and has been noted in cohorts of non-autistic patients with mitochondrial cytopathies [52].
Unsupervised analysis resulted in two major clusters – one mainly containing STS characterized by type-specific genetic alterations and the other with a predominance of genetically complex and pleomorphic STS.
Lentiviral-based expression of FTH1R23A in HCT116 cells leads to expression of FTH1R23A above endogenous FTH1 levels, with the predominance of ferritin complexes being composed of primarily the FTH1R23A subunit and sub-stoichiometry levels of endogenous wild type FTH1 that remains competent to bind NCOA4.
Drawing on the case of the old central business district in Tel Aviv and employing a mixed-method approach, this paper explores twenty years (1992 2012) of landuse regulation in which the initial strategy of office development has yielded to residential development challenging the predominance of the corporate-complex strategy.
The majority of the NTM species were respiratory pathogens known to cause intrathoracic disease, and previous reports of pediatric NTM disease have also documented a predominance of M. avium intracellulare complex, consistent with our findings [5], [6], [17].
Isolates from hematologic and dermatologic patients showed similar species distribution, with a predominance of F. solani species complex (FSSC) species 2 (69% and 74%, respectively).
The first pattern, corresponding to a predominance of medium-sized macrophages, involved complex surfaces with abundant small philopodial expansions.
On the other hand, the synthetic phenotype is characterized by the accumulation of cell organelles involved in proteosynthesis, such as endoplasmic reticulum, ribosomes or Golgi complex, and predominance of β- and γ-isoforms of actin and nonmuscle myosin.
