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Deeper understanding of the pathophysiology of osteoporosis and predisposition to fracture is necessary [ 5].
They proposed that the smaller cross-sectional diameter combined with increased body mass and minor trauma created a predisposition to fracture in these patients.
The sample size of patients that were included is relatively small to perform a fully powered statistical analysis and to make firm conclusions about the likelihood of genetic predisposition to fracture non-union.
Similar(54)
The increase in bone density weakens the bone, resulting in predisposition to fractures and osteomyelitis.
The clinical features of OI represent a continuum ranging from perinatal lethality through severe skeletal deformity, mobility impairment, and very short stature to nearly asymptomatic manifestation with mild predisposition to fractures, normal stature, and normal lifespan [ 4].
The role of canonical Wnt signaling in bone development and remodeling was first identified when the loss-of-function mutation of the LDL receptor-related protein (LRP5) was associated with osteoporosis psuedoglioma syndrome, a recessive disorder characterized by osteogenesis imperfecta with low bone mass and a predisposition to fractures as well as ocular defects [ 7, 8].
Is there a genetic predisposition to break ranks?
Dental defects arising as a result of OI represent one form of dentinogenesis imperfecta (DGI), which include reduced and defective dentin mineralization, alterations in tooth crown and root formation, and predisposition to tooth fractures and abscesses.
Osteoporosis (OP) is a skeletal disorder characterized by reduced bone strength and predisposition to increased risk of fracture, with consequent increased risk of morbidity and mortality.
Over-aggressive resection of the cam deformity has two potential adverse consequences: the loss of the sealing effect of the labrum in flexion and predisposition to iatrogenic femoral neck fracture.
Human twin and family linkage studies as well as animal model studies have confirmed the importance of genetic factors in the individual variance in peak bone mass acquisition, BMD, bone geometry, and metabolism and thus the predisposition to osteoporosis and related fragility fractures.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com