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In human medicine, HQ is used as a topical application in skin whitening to lighten the color of the skin as it does not have the same predisposition to cause dermatitis as metal does.
We hypothesize that perinatal exposures, in particular the human microbiome and maternal nutrition during pregnancy, interact with the genetic predisposition to cause an abnormal immune modulation in early life towards a trajectory to chronic inflammatory diseases such as asthma and others.
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The epidemiological, genetic and clinical disparities [12 14] are based on the predisposition to causes such as adhesive intestinal obstruction, differences in studied age groups and race-associated genetic differences.
Whether alteration of the host protein network by viruses participate or combine with these genetic predisposition factors to cause complexes diseases is an opened question and has to be investigated at the systems level.
Embryos of the + ct /+ ct strain do not develop NTDs or tail flexion defects, but, as they carry modifier genes from the curly tail background, we reasoned that embryos may exhibit predisposition to NTDs caused by an environmental insult such as folate deficiency.
For instance, cigarette smoking is known to cause predisposition to the development of lung cancer.
Germline alterations of TP53 are also thought to cause predisposition to breast cancer.
For example, genetic and environmental predisposition would be expected to cause a general, temporally nonspecific increase in the incidence of second cancers, while iatrogenic tumours resulting from the side effects of treatment for a first cancer would be expected to develop some time after this treatment.
Common migraine is a polygenic disease i.e. several genes have minor contributions to its pathophysiology and genetic predisposition combines with environmental triggers to cause clinical symptoms.
Excessive use of fruit juices in infancy and early childhood is NOT recommended because it has been shown to cause a predisposition to childhood obesity.
Noradrenergic and serotonergic deficits are believed to cause the seizure predisposition in GEPR and other mammals, which may be linked to depressive vulnerability [ 27].
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