We then determine the net predisposition to represent the aggregated effects of positive and negative evaluations.
COPD results from smoking/aeropollutant exposure and a genetic predisposition that represents the net effect of a variable number of genetic variants (SNPs, copy number variations, methylation, and others) that are conferring either a protective or susceptibility effect.
Groups at increased risk of colorectal cancer (e.g., those with a familial or other genetic predisposition) might still represent an appropriate group for an RCT as they would have the best chance of benefiting from chemoprevention, here although one would need to balance potential benefits against possible side effects.
Within twin pair sharing of pathways was viewed to represent "genetic predisposition" and were considered to not be sufficient to cause the disease; we labeled these predisposing pathways as GP1 in family 1 and GP2 in family 2. Naturally, the composition of GP1 and GP2 (GPN across n pairs of twins) is expected to differ between unrelated pairs.
This pretransplant metabolic profile may thus represent a predisposition to posttransplant fluid retention.
Furthermore, this phenotype could represent a predisposition to severe decline in hearing and balance due to aging, given the physiological loss of hair cells that occurs over the years.
These pathological cardiac changes could represent a predisposition to cardiac death and might themselves be serious enough to lead to death (as in our model), or be lethal in combination with other risk factors such as brain-stem malfunction.
Whether such changes occurs as an epiphenomenon secondary to daily stimulation or represent a structural predisposition to TN in the light of peripheral vascular compression is a matter of future studies.
So far it remained a matter of unresolved controversy in the neuroscience community, whether such cortical volume differences in the AC reflect neuroplastic effects due to intense training [32], [33] or represent an innate predisposition to a particular talent, i.e. musicality.
The prevalence of ARVC in our cohort is comparable with data from other European countries which may represent a genetic predisposition in Caucasian individuals and more awareness of this entity within Europe compared to the USA.
