Existing evidence for an ethnic predisposition points to a possible genetic idiosyncrasy [11], [12].
The preceding discussion suggests that Kwong loi Shun's summary is correct: in stating that human nature is good, "Mencius was saying that human beings have a constitution comprising certain emotional predispositions that already point in the direction of goodness and by virtue of which people are capable of becoming good….
"What's so interesting about this is that you would never find all of these pieces of data together unless you had a predisposition to a particular point of view," said David A. Harris, a professor of law and values at the University of Toledo College of Law and author of "Profiles in Injustice," to be published in February.
Therefore, the first inference to avoid is that DNA adduct formation or alterations in the promoter methylation of a gene causes cancer in the absence of inherited or acquired predisposition (i.e., a point germline mutation of a tumor suppressor gene or an acquired sporadic mutation).
In addition to the ability to be impulsive and adaptable (in other words, to have a predisposition to action), entrepreneurs Mehta points to Cambridge University research that identifies the ability to take risky bets as the single biggest entrepreneurship differentiator between people with similar abilities and IQs.
Recently, there is growing evidence pointing to hereditary predisposition and biological characteristics of the eutopic endometrium as the determinative factors in the pathogenesis of MTOE.
The same constitutive activation was found for components of the IRE1 and PERK pathways [ 424], thus pointing toward a predisposition of tumor cells to be able to cope with PDT-induced proteotoxic stress.
Yet, paradoxically, this concordance difference in smoking behaviour is not reflected in a concordance difference for lung cancer, although in female twins, where the prevalence is much lower, it did appear to follow a more conventional genetic pattern with risks in MZ being greater than in DZ twins, pointing to genetic predisposition (Lichtenstein et al, 2000).
Although HIF dysregulation is critical to VHL disease-associated renal tumorigenesis, increasing evidence points toward gradations of HIF dysregulation contributing to the degree of predisposition to renal cell carcinoma and other manifestations of the disease.
This is what pushed him, in 1984, to create the Center for the Study of Human Polymorphisms, with the aim of detecting, in the genome, the genes of predisposition that were up to that point only suspected, even those not included in the HLA system.
