Our results involving the genetic analysis of 50+ rhesus macaques with and without gluten sensitivity indicate that a Mamu II-associated predisposition for this condition exists in rhesus monkeys[Sestak et al., unpublished].
In addition, hypertensive patients are more salt sensitive than normotensive subjects [4] and normotensive subjects with heredity for hypertension have increased salt sensitivity [6], indicating that salt sensitivity is partially related to an inherited predisposition for hypertension.
Using a novel approach, we have shown that breakage events of a genomic region in independent lineages are significantly correlated, thus indicating that the predisposition of a genomic region for breakage is conserved over long evolutionary distances.
The STAT4 risk allele on chromosome 2 was also recently demonstrated to be associated with LN as well as with the development of severe renal insufficiency, thus further indicating that genetic predisposition is of importance for disease progression in LN [ 11].
Yet, rather surprising parallelisms have evolved in species flocks of the different lakes [ 3, 5, 8] indicating that the genetic "predisposition" for the modification of these traits might have been already present in the genome of the common ancestor of all the East African cichlid species.
In only one patient (P2 in de Bruin et al, 2015), a malignant tumor was reported, indicating that XRCC4 impairment is not strongly associated with predisposition to malignancy.
41 This study provides evidence for a role of Srp9 in both FS and mTLE, thus indicating that they share at least some common genetic predisposition.
However, this association could not be replicated in an independent set of 81 smaller families (173 nuclear families, Set II) also originating from France, indicating that different genetic factors may be involved in the predisposition to psoriasis in our population.
This is particularly relevant, given that our study population accounted for a highly significant proportion of the African diaspora, indicating that both populations may harbor similar inherited genetic predispositions that trigger alterations associated with increased risk of prostate cancer.
Additionally, E is shown to be dependent on S3, indicating that there is a genetic component to exposure (a genetic predisposition to smoking, for example).
