Female gender, hereditary predisposition, increasing age and body-mass index (BMI) were associated with increased prevalence of gallstones.
He further adds that "predisposition increases the risk for certain cancers, depending on which gene has a mutation.
The second explanation is that a genetic predisposition increases the probability of developing mood and anxiety disorders.
These include high tobacco and/or alcohol consumption, hormonal and nutritional factors, exposure to virus and immunosuppression, genetic predisposition, increased site-specific medical surveillance, late adverse effects of first cancer treatments and interactions among these factors [ 4, 5, 15].
There was a large significant difference between the profiles of the non-OA and OA specimens, which could be due to predisposition, increased turnover, or change in loading across the joint.
An early onset of disease probably reflects increased biological predisposition or increased susceptibility to specific environmental risk factors [57].
Genetic predisposition may increase the likelihood of developing T2DM, but environmental factors, including obesity, sedentary lifestyles, and age, increase the risk of developing insulin resistance.
Genetic predisposition may increase the risk of developing HLH/MAS in some patients (Maude et al., 2014b), but it can be well controlled by tocilizumab.
Recent retro spective studies and case reports suggest that long-term BP therapy may result in the suppression of bone turn over and confer a predisposition to increased bone fragility, with an increased risk of atypical fractures [ 62].
Biallelic loss of PALB2 causes increased predisposition to cancers, increased sensitivity to DNA-damaging agents, and Fanconi anemia [ 8].
Osteoporosis (OP) is a skeletal disorder characterized by reduced bone strength and predisposition to increased risk of fracture, with consequent increased risk of morbidity and mortality.
