Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the prevalent tumors.
Neurofibromatosis type 1 (NF1) is one of the most common brain tumor predisposition syndromes, in which affected children are prone to the development of low-grade gliomas.
These are inherited tumor predisposition syndromes in which hamartomas may develop in the central nervous system, gastrointestinal tract, skin, breast and thyroid [33].
GWAS is a powerful method for the detection of genetic contributions to polygenic diseases, and it has been used to identify genetic predisposition in AIS, which has been recently regarded as one of the most common complex genetic disorders of the musculoskeletal system [ 6, 15].
Lead poisoning inhibits excretion of the waste product urate and causes a predisposition for gout, in which urate builds up.
In Die Religion innerhalb der Grenzen der bloßen Vernunft (Religion Within the Boundaries of Mere Reason) (1793) Kant calls reverential respect for the moral law as it itself sufficient to motivate action the "predisposition to personality," which is that "original predisposition" in human nature which makes it possible for us to be moral beings (Religion 6 21 23).
Conformational changes in Ire1's kinase domain modulate the enzyme's predisposition to form oligomers, in which Ire1-Ire1 contacrosscross multiple interfaces activate Ire1's RNase activity.
The distinct negative association between alpha diversity and frailty reflects observations from numerous studies in which predisposition to ill health associates reduced diversity [ 28– 31].
Lynch syndrome is a dominantly inherited cancer syndrome in which predisposition to colorectal, endometrial, and other cancers occurs due to an underlying defect in the cellular mismatch repair (MMR) system.
In combination, the structural rearrangements in CDK2 and the presented functional and structural observations with Ire1 converge on a model in which predisposition toward the active conformation of the kinase domain (defined by the position of the αC-helix) is tightly coupled to β-phosphate docking of bound nucleotide (a β-phosphate latch).
