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The role of SLC45A2 in melanoma predisposition was further analyzed in relation to MC1R, the main low penetrance gene associated to melanoma.
Our evaluation of genetic predisposition for breast cancer in relation to three different environmental risk factors found no significant gene-environment interactions.
This data certainly support the importance of genetic changes in the OGG1 gene in relation to the predisposition to cancer.
The latter explanation has been reported for reactive airway disease (mainly manifested as wheeze) in relation to RSV predisposition (28 – 328).
Objective To examine the interactions between genetic predisposition and consumption of fried food in relation to body mass index (BMI) and obesity.
The shared epitope (SE) concept in relation to genetic predisposition was first described in 1986 and has evolved from the classic HLA-DRB1*01, HLA-DRB1*04 and HLA-DRB1*10 associations [ 2- 4] to the identification of the RAA amino acid motif at positions 72 to 74 of the third hypervariable region of the different human leucocyte antigen (HLA -DRB1 cHLA -DRB1the definitive SE [ 3- 5].
In BC patients, cancer (recurrence) risk perception may be experienced not solely in relation to the genetic predisposition to cancer, so we only focused on the perceived probability of genetic predisposition to cancer as a moderator of psychological outcomes.
AATF sequence alterations have not previously been studied in relation to breast cancer predisposition.
Other reasons may be sought in an altered metabolism of AD patients, e.g., in relation to known genetic predispositions.
This clearly showed an increased predisposition to proliferation by the MCT-derived fibroblasts in relation to low dose serum stimulation.
Outside of the context of cancer predisposition syndromes, most studies have investigated SMN risks in relation to specific genes, selected based on understanding of biologic pathways of drug metabolism and carcinogenesis.
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