Exact(4)
External apical root resorption (EARR) presents with a multi-factorial etiology, individual predisposition being one of the factors [ 8– 10].
Epidemiological studies show a strong association of MHC region with disease predisposition, being related to the presence of 'shared epitopes' of HLA-DRB1, which includes the DRB1*04 and DRB1*01 alleles.
Based on all of these previously published hypotheses, we think that a multifactorial aetiology is the best match with regard to BEN pathophysiology, with a genetic predisposition being the 'condicio sine qua non' for the development of BEN.
Interestingly, a strong association of SS with genes encoding for HLA molecules has been reported, implicating a genetic predisposition being associated with the disease SS [ 36], and thus stressing the importance of performing further studies on antigen-presenting functions in these patients.
Similar(56)
But a predisposition is not destiny.
Silver said his predisposition was for telephone polls.
"Genetic predisposition is like the colour of your eyes.
An innate predisposition isn't enough for oscine songbirds to learn their repertoire, Pepperberg said.
Clearly a predisposition is required, and this is highly likely to be genetic.
Cameron's predisposition is to leave well alone, so do not expect too many fireworks.
But predisposition is not a guarantee that an individual will develop the disease.
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