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We believe that such a dual anabolic strategy would be ideal for the setting of OI, where low bone mass and fracture lead to reduced physical activity, which results in muscle atrophy and further reduction in bone mass, further predisposing to fracture, and so on.
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Osteoporosis is a disabling condition predisposing to fractures in both women and men [ 1].
The patient had no history of prior chest trauma, and there were no overt medical conditions predisposing to fractures.
Alternatively, if periosteal apposition is impaired, endosteal resorption will produce cortical thinning and loss of bone mass and strength, predisposing to fractures.
Osteoporosis is a common disorder in the elderly population, and represents one of the most significant public health problems in the world, predisposing to fractures with minimal or no antecedent trauma.
The narrow cross section of the bone in the middle shaft combined with typical muscle forces acting over it predispose to fracture the bone in this locality.
However, investigations of the underlying structural changes that might predispose to fracture have been largely limited to skeletal sites that do not fracture, such as the iliac crest (IC).
Indeed, the study of bone turnover markers in acute Charcot neuroarthropathy shows that there is an increase in osteoclast activity compared with osteoblast activity (9); this can lead to osteopenia, which could predispose to fracture, even as a consequence of minimal trauma.
Varus malpositioning predisposes to fractures of the femoral stem.
Osteoporosis is a disease associated with low bone mass, which predisposes to fractures.
The results of the present study show that bone microstructure undergoes age-related changes, which may predispose to fractures.
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