While certain individuals might be predisposed to back problems by an inherited weakness or a malformation of the spine, the majority of back sufferers "have brought on the problems themselves," Landell says.
Hereditary Nonpolyposis Colorectal Cancer (HNPCC or "Lynch syndrome"), involving pathogenic variants in the Mismatch Repair (MMR) genes, is the most common inherited condition that predisposed to colorectal adenomas and colorectal cancer.
Their female offspring inheriting this polymorphism is predisposed to precocious puberty.
That is, most cancers arise in organs that are predisposed to cancer due to an interplay of inherited and exogenous influences (i.e., gene x environment interactions).
This parallels p53 loss of function that occurs in many types of solid tumors and in individuals with the Li-Fraumeni syndrome who are predisposed to breast and other cancer because of inherited loss of p53 (22, 22).
Several studies have suggested that those who inherit the APOEε4 gene may be predisposed to development of some disorders including atherosclerosis and AD [ 22, 25].
Women who inherit a germline mutation in the BRCA2 gene are predisposed to breast cancer [ 1].
Inactivating mutations in the LKB1 kinase tumour suppressor gene cause the inherited Peutz Jeghers cancer syndrome, in which patients are predisposed to developing benign and malignant tumours [ 1].
Besides the above-mentioned inherited conditions, tumor multiplicity is also a frequent observation in patients with CRC who are not apparently predisposed to these neoplasms on the basis of their genetic background.
If the deletion is inherited, the classic pattern observed is the formation of multiple tumors in the susceptible tissue, since each cell is in principle predisposed to cancer.
Patients who inherit BRCA1 or BRCA2 mutations, have an increased susceptibility to develop breast and ovarian cancers, whereas FA patients can have congenital defects and are predisposed to developing leukaemia and various solid tumours.
